Benzodiazepine-reversal agent
Acute reversal of benzodiazepine overdose in procedural sedation
Dose, BDZ-sedation reversal:
0.2 mg IV over 15 seconds. May repeat q20min. Max dose 1 mg total.
Dose, BDZ overdose:
0.2 mg IV over 30 seconds. Then 0.3 mg IV over 30 seconds. Then 0.5 mg IV over 30 seconds q1min PRN. Max dose 5 mg total.
Indications
Warning
Can theoretically precipitate seizure activity in patients who chronically take benzodiazepines or chloral hydrate.
Contraindications
Patient exhibiting seizure activity
Co-ingestion of drugs with pro-convulsant properties (e.g. TCAs) due to increased risk of seizures
Content on this page has not been checked for accuracy. The author's credentials have not been confirmed. Always use multiple peer-reviewed scholarly sources and good clinical judgement in your decision making.
The Compendium platform was created by David Kwinter, MD, CCFP(EM).
Dr. Kwinter is a Cayman Family Doctor. He runs a Family Medicine Clinic at Cayman Medical in George Town, Grand Cayman, Cayman Islands.
Dr. Kwinter is a Cayman Family Doctor. He runs a Family Medicine Clinic at Cayman Medical in George Town, Grand Cayman, Cayman Islands.