Bacteriocidal. Inhibits mycolic acid biosynthesis. Also disrupts DNA, lipid, carbohydrate and NAD synthesis and metabolism.
See also
Respiratory Infection Formulary
Indication
Part of DOTS (directly observed therapy)
DOTS has a success rate exceeding 95% and prevents the emergence of further MDR-strains.
Latent TB
A/E
Drug-induced hepatitis
Peripheral neuropathy (uncommon), can be minimized by coadministration of Vitamin B6 (pyridoxine)
Note
Available IM or in combination pills
Safe in pregnancy
Contraindications
Caution in liver failure, increased risk for hepatotoxicity
Content on this page has not been checked for accuracy. The author's credentials have not been confirmed. Always use multiple peer-reviewed scholarly sources and good clinical judgement in your decision making.
The Compendium platform was created by David Kwinter, MD, CCFP(EM).
Dr. Kwinter is a Cayman Family Doctor. He runs a Family Medicine Clinic at Cayman Medical in George Town, Grand Cayman, Cayman Islands.
Dr. Kwinter is a Cayman Family Doctor. He runs a Family Medicine Clinic at Cayman Medical in George Town, Grand Cayman, Cayman Islands.